CPH+ FOR BEAUTY FROM THE INSIDE OUT

A healthy lifestyle with great – and lasting – looks

In Japan, for example, a daily dose of collagen peptides has long been recognized as a vital contributor to anti-aging effects and great looks. Today, science is increasingly affirming this timeless philosophy.

The lines between wellness and beauty are blurring, as consumers increasingly appreciate the fact that a healthy lifestyle, including the right nutrition, can help us feel better and look better, too. Surveys show that People today understand that beautiful skin on the outside requires a healthy foundation on the inside – and that they are consequently taking a more holistic approach to their health regimes 2.

A powerful anti-aging ingredient fights

against the visible signs of aging

The star player in the arena of ingestible beauty ingredients

In the arena of ingestible beauty products, collagen has long been recognized as the star player. Research shows that collagen is now the leading functional ingredient of beauty products in all regions of the world.

The bad news for beauty: our collagen production wanes as we grow older

Collagen is the most abundant protein in the human body, constituting 70% of our dry-mass skin content 4. A key component of the skin’s structure, collagen fibers provide the infrastructure for elastin, which maintains skin elasticity, and for hyaluronic acid, which holds moisture. As we age, both the number and the activity of skin cells (fibroblasts) that produce collagen decrease. The collagen matrix that provides skin firmness and structure starts to break down and our skin becomes dehydrated and thinner, with fine lines, wrinkles and deeper furrows start to appear…

The good news: the right nutrition can make skin look younger and more beautiful

Scientific research has proven that nutrition can vitally influence our skin’s elasticity, firmness and moisture-binding capacity by contributing to optimum levels of well-organized collagen fibers. Collagen peptides, in particular, have proven skin beauty benefits, contributing to a healthier, younger-looking skin.

References

1 The Global Nutricosmetics Market: Trends, Drivers & Projections, Global Industry Analysts Inc., 2015.

2 Dryza, Deep Beauty. VANVAS8. Report, 2012.

3 Innova, trends in nutricosmetics, 2016

4 Gniadecka, M. et al., 1998, Water and Protein Structure in Photoaged and Chronically Aged Skin. Journal of Investigative Dermatology, 111(6):1129-1132

Science’s answer to skin dehydration, wrinkles and sagging

CPH+ , the bioactive ingredient for rejuvenation and hydration Research has confirmed how collagen peptides help strengthen and rejuvenate the deeper skin layers from within, maintaining the cohesive and dense collagen network that is key to preventing wrinkles and sagging. CPH+  collagen peptides also have a significant effect on skin hydration. Maintaining a well-hydrated skin is crucial for a smooth, healthy-looking skin and prevents the formation of micro relief wrinkles. In this section, we invite you to take a closer look at the science behind skin beauty.

  • Restructuring the skin’s collagen network from within

As our skin ages and responds to external conditions, like sunlight, the collagen in the dermis begins to get damaged and fragmented. This can hinder collagen synthesis and elastin production, leading to a loss of elasticity and a reduction of the skin’s total collagen density. With CPH+ , you can create solutions that will counter these effects.

  • Visible effects after just one month of use

In several clinical studies, visible skin health and beauty effects have been demonstrated after just one month of use 5,6.  

References:

  1. Asserin, J. et al., 2015, The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14:291-301. doi: 10.1111/jocd.12174

6 Borumand, M. et al., 2014, Daily consumption of the collagen supplement reduces visible signs of aging. Clinical Interventions in Aging, 9:1747-1758

  • Less deep-layer defragmentation, higher collagen density

A randomized, placebo-controlled, double-blind clinical trial by COSderma in France 5 involving 106 women, showed that after just four weeks of consumption of fish collagen peptides, collagen fragmentation decreased significantly (by 18%) in the deep layers of the skin. After 12 weeks of Collagen intake, there was a 31% reduction. The same study showed a 9% increase of the density of collagen in the dermis after four weeks of Collagen intake.

  • Enhancing skin hydration

Environmental pollution, aging and harmful ultraviolet rays can damage collagen fibers, limit hyaluronic acid production and decrease water content in our skin. This dehydration can cause it to look tired and wrinkled. A daily dose of CPH+ can increase not only the skin’s collagen density, but also its moisture levels, while decreasing and plumping wrinkles. A double-blind, placebo-controlled trial of collagen peptides among 33 women (aged 40-59) by Souken in Japan5 showed that Collagen increased skin hydration by 28% after eight weeks. 91% of this research group reported a higher skin hydration level during the same period.

Immediate results with collagen as an active ingredient A recent skin study, in which a group of individuals took Collagen as an active ingredient in a nutritional supplement , showed a positive anti-aging effect on their skin, with fewer wrinkles and an increase in skin moisture and collagen density 6.

How Collagen  works: the mechanism behind skin beauty

One Collagen , multiple skin benefits

Thanks to the latest research, we understand today better the unique mechanisms behind Collagen Peptides . We know enough today to understand the vital mechanisms behind it. Key findings include the fact that ingesting collagen peptides can improve several skin properties, such as elasticity and smoothness, and significantly increase skin hydration.

How Collagen Peptides works: the mechanism behind skin beauty  

  • Giving the body a clear message

After consuming Collagen , small hydroxyproline-containing peptides appear in the blood stream. Scientists believe these give off a false signal, suggesting to the body that its own collagen is being destroyed. Thus collagen peptides may act as a messenger, triggering the synthesis and reorganization of new collagen fibers by stimulating fibroblast cells 7,8,9.

  • Stimulating the expression of elastin and GAGs

Collagen have also been shown to stimulate the expression of elastin and glycosaminoglycans (GAGs), such as hyaluronic acid (HA) 8,9. Studies have shown collagen peptides to improve skin elasticity and dermis echogenicity 10,11. Ex-vivo skin studies using histological techniques have confirmed increased collagen and GAG production in the dermis, following the addition of Collagen to the skin explants’ culture medium 5.

  • Improving the skin’s mechanical strength

Additional studies have shown that collagen peptides can enhance the fibroblast density and the thickness of collagen fibrils in the dermis and may improve the mechanical strength of the skin by increasing the decorin ratio12,13. Morphology of a skin explant sample treated with Collagen . The density of the collagen fibers (green color) is enhanced. The untreated control explant sample with less dense coloration due to less collagen present. Stratum corneum Epidermis Papillary dermis Collagen structure (with Fish Collagen Peptide ) Stratum corneum Epidermis Papillary dermis Collagen structure

Fish Collagen’s high bioavailability and bioactivity means immediate, maximum benefits

CPH+ Collagen peptides are optimized for high bioavailability and bioactivity. This means they quickly reach the parts of the body where they are most needed – and with maximum effect. In fact, 90% of CPH+ collagen peptides are digested and available within the connective tissues just a few hours after digestion. From the blood, the peptides – containing hydroxyproline, a unique amino acid – are transported into the target tissues, where they act as building blocks for the local cells and help boost the production of new collagen fibers14.

References:

7 Postlethwaite, A. E. et al., 1978, Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proceedings of the National Academy of Sciences, 75(2):871-875

8 Shigemura, Y. et al., 2009, Effect of Prolyl-hydroxyproline (Pro-Hyp), a Food-Derived Collagen Peptide in Human Blood, on Growth of Fibroblasts from Mouse Skin. Journal of Agricultural and Food Chemistry, 57(2):444- 449

9 Ohara, H. et al., 2010, Effects of Pro-Hyp, a Collagen Hydrolysate Derived Peptide, on Hyaluronic Acid Synthesis Using in Vitro Cultured Synovium Cells and Oral Ingestion of Collagen Hydrolysates in a Guinea Pig Model of Osteoarthritis. Bioscience, Biotechnology, and Biochemistry, 74(10):2096-2099

10 Campos, Mbg, P. M. et al., 2015, An Oral Supplementation Based on Hydrolyzed Collagen and Vitamins Improves Skin Elasticity and Dermis Echogenicity: A Clinical Placebo-Controlled Study. Clinical Pharmacology & Biopharmaceutics, 04(03)

11 Matsumoto, et al., 2006, Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Letters on Batteries, New Technologies and Medicine, 7(4):386-390

12 Matsuda, N. et al., 2006, Effects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in the Dermis. Journal of Nutritional Science and Vitaminology, 52(3):211-215

13 Liang, J. et al., 2010, The Protective Effects of Long-Term Oral Administration of Marine Collagen Hydrolysate from Chum Salmon on Collagen Matrix Homeostasis in the Chronological Aged Skin of Sprague-Dawley Male Rats. Journal of Food Science, 75(8)

14 Watanabe-Kamiyama, M. et al., 2010, Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats. Journal of Agricultural and Food Chemistry, 58(2):835-841 R

CPH+  is the supplement of choice for efficient and trustworthy Beauty From Within solutions.

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